Academic research is with many types of barriers, and breaking through those barriers is an important challenge to explore new possibilities of academic research. An important challenge is to develop technology and strategy to go beyond various barriers, such as a barrier that divides communities, or a barrier that prevents the usage of data. The purpose of this presentation is to introduce case studies on research infrastructure that has been developed by the presenter, such as Digital Typhoon, Digital Silk Road, and Digital Archives of East Japan Great Earthquake, to discuss what kind of barriers we faced, and how we broke the barriers. The same problem is also critical in "Open Science," and the presentation delivers personal opinions on how informatics can contribute to the solution of the problem.